Restoring function after spinal cord injury: Promoting spontaneous regeneration with stem cells and activity-based therapies

被引：25

作者：

Belegu, Visar

Oudega, Martin

Gary, Devin S.

McDonald, John W.

机构：

[1] Johns Hopkins Univ, Kennedy Krieger Inst, Int Ctr Spinal Cord Injury, Sch Med,Dept Neurol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Phys Med & Rehabil, Baltimore, MD 21205 USA

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2007年 / 18卷 / 01期

关键词：

D O I：

10.1016/j.nec.2006.10.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although neural regeneration is an active research field today, no current treatments can aid regeneration after spinal cord injury. This article reviews the feasibility of spinal cord repair and provides an overview of the range of strategies scientists are taking toward regeneration. The major focus of this article is the future role of stem cell transplantation and simpler rehabilitative restorative approaches designed to optimize spontaneous regeneration by mobilizing endogenous stem cells and facilitating other cellular mechanisms of regeneration, such as axonal growth and myelination.

引用

收藏

页码：143 / +

页数：27

相关论文

共 157 条

[1] Spinal shock [J].

Atkinson, PP ;

Atkinson, JLD .

MAYO CLINIC PROCEEDINGS, 1996, 71 (04) :384-389

[2] Induction of endogenous neural precursors in mouse models of spinal cord injury and disease [J].

Azari, MF ;

Profyris, C ;

Zang, DW ;

Petratos, S ;

Cheema, SS .

EUROPEAN JOURNAL OF NEUROLOGY, 2005, 12 (08) :638-648

[3]

Bammer R, 2000, AM J NEURORADIOL, V21, P587

[4] Does neurorehabilitation play a role in the recovery of walking in neurological populations? [J].

Barbeau, H ;

Norman, K ;

Fung, J ;

Visintin, M ;

Ladouceur, M .

NEURONAL MECHANISMS FOR GENERATING LOCOMOTOR ACTIVITY, 1998, 860 :377-392

[5] Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays [J].

Bareyre, FM ;

Schwab, ME .

TRENDS IN NEUROSCIENCES, 2003, 26 (10) :555-563

[6] MR DIFFUSION TENSOR SPECTROSCOPY AND IMAGING [J].

BASSER, PJ ;

MATTIELLO, J ;

LEBIHAN, D .

BIOPHYSICAL JOURNAL, 1994, 66 (01) :259-267

[7] Restoring function after spinal cord injury [J].

Becker, D ;

Sadowsky, CL ;

McDonald, JW .

NEUROLOGIST, 2003, 9 (01) :1-15

[8] A REVIEW OF CERVICAL-SPINE INJURIES WITH NEUROLOGICAL DYSFUNCTION [J].

BEDBROOK, GM ;

SAKAE, T .

PARAPLEGIA, 1982, 20 (06) :321-333

[9] Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth [J].

Benson, MD ;

Romero, MI ;

Lush, ME ;

Lu, QR ;

Henkemeyer, M ;

Parada, LF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) :10694-10699

[10] CELLULAR MORPHOLOGY OF CHRONIC SPINAL-CORD INJURY IN THE CAT - ANALYSIS OF MYELINATED AXONS BY LINE-SAMPLING [J].

BLIGHT, AR .

NEUROSCIENCE, 1983, 10 (02) :521-&

← 1 2 3 4 5 6 7 8 9 10 →