Restoring function after spinal cord injury: Promoting spontaneous regeneration with stem cells and activity-based therapies

被引：25

作者：

Belegu, Visar

Oudega, Martin

Gary, Devin S.

McDonald, John W.

机构：

[1] Johns Hopkins Univ, Kennedy Krieger Inst, Int Ctr Spinal Cord Injury, Sch Med,Dept Neurol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Phys Med & Rehabil, Baltimore, MD 21205 USA

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2007年 / 18卷 / 01期

关键词：

D O I：

10.1016/j.nec.2006.10.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although neural regeneration is an active research field today, no current treatments can aid regeneration after spinal cord injury. This article reviews the feasibility of spinal cord repair and provides an overview of the range of strategies scientists are taking toward regeneration. The major focus of this article is the future role of stem cell transplantation and simpler rehabilitative restorative approaches designed to optimize spontaneous regeneration by mobilizing endogenous stem cells and facilitating other cellular mechanisms of regeneration, such as axonal growth and myelination.

引用

收藏

页码：143 / +

页数：27

相关论文

共 157 条

[11] ACUTE SPINAL-CORD INJURY - A STUDY USING PHYSICAL-EXAMINATION AND MAGNETIC-RESONANCE-IMAGING [J].

BONDURANT, FJ ;

COTLER, HB ;

KULKARNI, MV ;

MCARDLE, CB ;

HARRIS, JH .

SPINE, 1990, 15 (03) :161-168

[12]

Bregman B S, 1983, Brain Res, V285, P119

[13] RECOVERY OF FUNCTION AFTER SPINAL-CORD INJURY - MECHANISMS UNDERLYING TRANSPLANT-MEDIATED RECOVERY OF FUNCTION DIFFER AFTER SPINAL-CORD INJURY IN NEWBORN AND ADULT-RATS [J].

BREGMAN, BS ;

KUNKELBAGDEN, E ;

REIER, PJ ;

DAI, HN ;

MCATEE, M ;

GAO, D .

EXPERIMENTAL NEUROLOGY, 1993, 123 (01) :3-16

[14] Inhibition of Nogo: A key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system [J].

Buchli, AD ;

Schwab, ME .

ANNALS OF MEDICINE, 2005, 37 (08) :556-567

[15] A new millenium for spinal cord regeneration: Growth-associated genes [J].

Bulsara, KR ;

Iskandar, BJ ;

Villavicencio, AT ;

Skene, JHP .

SPINE, 2002, 27 (17) :1946-1949

[16] Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components [J].

Carulli, D ;

Rhodes, KE ;

Brown, DJ ;

Bonnert, TP ;

Pollack, SJ ;

Oliver, K ;

Strata, P ;

Fawcett, JW .

JOURNAL OF COMPARATIVE NEUROLOGY, 2006, 494 (04) :559-577

[17] Oligodendroglial apoptosis occurs along degenerating axons and is associated with Fas and p75 expression following spinal cord injury in the rat [J].

Casha, S ;

Yu, WR ;

Fehlings, MG .

NEUROSCIENCE, 2001, 103 (01) :203-218

[18]

Cercignani M, 2003, AM J NEURORADIOL, V24, P1254

[19] Axonal regeneration from CNS neurons in the cerebellum and brainstem of adult rats: Correlation with the patterns of expression and distribution of messenger RNAs for L1, CHL1, c-jun and growth-associated protein-43 [J].

Chaisuksunt, V ;

Zhang, Y ;

Anderson, PN ;

Campbell, G ;

Vaudano, E ;

Schachner, M ;

Lieberman, AR .

NEUROSCIENCE, 2000, 100 (01) :87-108

[20]

*CHRIST REEV FDN, 2006, NEURORECOVERY NETWOR

← 1 2 3 4 5 6 7 8 9 10 →