A mild, convenient, and inexpensive method for converting imines into amines: Tin-catalyzed reduction with polymethylhydrosiloxane (PMHS)

被引：55

作者：

Lopez, RM ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

TETRAHEDRON | 1997年 / 53卷 / 48期

关键词：

D O I：

10.1016/S0040-4020(97)01020-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a mild, convenient, and inexpensive protocol for reducing imines to amines. Thus, treatment of any of a wide array of imines with catalytic n-butyltris(2-ethylhexanoate)tin and stoichioimetric polymethylhydrosiloxane (PMHS) in ethanol at room temperature cleanly affords the desired secondary amine product. Alkyl bromides, alkynes, epoxides, esters, nitriles, and olefins are inert toward these reduction conditions, whereas aldehydes, ketones, and nitro compounds are not. (C) 1997 Elsevier Science Ltd.

引用

页码：16349 / 16354

页数：6

共 23 条

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