Inhibitory effect of traditional Turkish folk medicines on aldose reductase (AR) and hematological activity, and on AR inhibitory activity of quercetin-3-O-methyl ether isolated from Cistus laurifolius L.

被引：37

作者：

Enomoto, S

Okada, Y

Güvenc, A

Erdurak, CS

Coskun, M

Okuyama, T

机构：

[1] Meiji Pharmaceut Univ, Dept Natl Med & Phytochem, Tokyo 2048588, Japan

[2] Ankara Univ, Fac Pharm, TR-06100 Ankara, Turkey

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2004年 / 27卷 / 07期

关键词：

Cistus Laurifolius; complications of diabetes; quercetin-3-O-methyl ether; human aldose reductase; platelet aggregation; blood coagulation;

D O I：

10.1248/bpb.27.1140

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The inhibitory effects of 40 extracts prepared from 38 traditional Turkish folk medicines on human aldose reductase (h-AR) and hematological activity were investigated. Seven plants containing 5 species of Cistus genus exhibited a potent inhibition of h-AR. Ferulago amani (root) inhibited the platelet aggregation induced by sodium arachidonate, while C. laurifolius (fruit) was found to possess strong inhibition in the blood coagulation assay. An AcOEt extract derived from the leaf of C laurifolius was purified to isolate three known flavonoids. The activity of one, quercetin-3-O-methyl ether, was found to be as potent as that of eparlestat, which is known to be a remedy for treating complications associated with diabetes.

引用

页码：1140 / 1143

页数：4

共 21 条

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