Novel antiplatelet naphthalene from Rhamnus nakaharai

被引：26

作者：

Li, CN ^{[1
]}

Lu, CM ^{[1
]}

Ko, FN ^{[1
]}

Teng, CM ^{[1
]}

机构：

[1] NATL TAIWAN UNIV,INST PHARMACOL,COLL MED,TAIPEI 100,TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1995年 / 58卷 / 12期

关键词：

D O I：

10.1021/np50126a023

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new naphthalene derivative, isotorachrysone [1], was isolated from the stem bark of Rhamnus nakaharai along with several known compounds. The antiplatelet effects of isotorachrysone [1], isotorachrysone peracetate [2], 6-methoxysorigenin [3], quercetin 3-O-methyl ether [4], and quercetin 3-O-methyl ether peracetate [5] were studied using washed rabbit platelets. Of the compounds rested, 1, 2, 4, and 5 showed potent antiplatelet effects on arachidonic acid (AA-) and collagen-induced platelet aggregation. Compound 5 also showed potent antiplatelet, effects on platelet-activating factor-(PAF-) induced platelet aggregation. Isotorachrysone [1] and its peracetate [2] were also studied for antiplatelet activity in human platelet-rich plasma (PRP) and both showed potent inhibition of the secondary aggregation induced by epinephrine. The antiplatelet effects of 1 and 2 are due partially co an inhibitory effect on thromboxane formation.

引用

页码：1934 / 1940

页数：7

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