Pharmacologic resistance in colorectal cancer: a review

被引：444

作者：

Hammond, William A. ^{[2
]}

Swaika, Abhisek ^{[2
]}

Mody, Kabir ^{[1
]}

机构：

[1] Mayo Clin, Ctr Canc, Div Hematol Oncol, Jacksonville, FL 32224 USA

[2] Mayo Clin, Div Hematol Oncol, Jacksonville, FL 32224 USA

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2016年 / 8卷 / 01期

关键词：

colon adenocarcinoma; colon cancer; resistance; GROWTH-FACTOR RECEPTOR; GENE COPY NUMBER; THYMIDINE PHOSPHORYLASE EXPRESSION; THYMIDYLATE SYNTHASE EXPRESSION; TOPOISOMERASE-I GENE; DNA MISMATCH REPAIR; PHASE-III TRIAL; OXALIPLATIN-BASED CHEMOTHERAPY; FLUOROURACIL PLUS LEUCOVORIN; ANTI-EGFR THERAPY;

D O I：

10.1177/1758834015614530

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Colorectal cancer (CRC) persists as one of the most prevalent and deadly tumor types in both men and women worldwide. This is in spite of widespread, effective measures of preventive screening, and also major advances in treatment options. Despite advances in cytotoxic and targeted therapy, resistance to chemotherapy remains one of the greatest challenges in long-term management of incurable metastatic disease and eventually contributes to death as tumors accumulate means of evading treatment. We performed a comprehensive literature search on the data available through PubMed, Medline, Scopus, and the ASCO Annual Symposium abstracts through June 2015 for the purpose of this review. We discuss the current state of knowledge of clinically relevant mechanisms of resistance to cytotoxic and targeted therapies now in use for the treatment of CRC.

引用

页码：57 / 84

页数：28

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