Highly Enantioselective Synthesis of Chiral Secondary Amines by Gold(I)/Chiral Bronsted Acid Catalyzed Tandem Intermolecular Hydroamination and Transfer Hydrogenation Reactions

被引：163

作者：

Liu, Xin-Yuan

Che, Chi-Ming ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 18期

关键词：

TRANSITION-METAL CATALYSIS; MICROWAVE-ASSISTED CONDITIONS; PHASE-TRANSFER CATALYST; ASYMMETRIC HYDROAMINATION; COOPERATIVE CATALYSIS; ALLYLIC ALKYLATION; INTRAMOLECULAR HYDROAMINATION; REDUCTIVE AMINATION; RELAY CATALYSIS; GOLD CATALYSIS;

D O I：

10.1021/ol901443b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the synthesis of enantiomerically enriched secondary amines with excellent ee values through the tandem intermolecular hydroamination/transfer hydrogenation of alkynes using a "gold(I) complex-chiral Bronsted acid" protocol is developed. The catalysis works for a wide variety of aryl, alkenyl, and aliphatic alkynes as well as anilines with different electronic properties.

引用

页码：4204 / 4207

页数：4

共 55 条

[51] Recent developments in enantioselective gold(I) catalysis [J].