Antagonism of activin by inhibin and inhibin receptors: a functional role for betaglycan-glycan (vol 180, pg 47, 2001)

被引：48

作者：

Gray, PC ^{[1
]}

Bilezikjian, LM ^{[1
]}

Vale, W ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Clayton Fdn Labs Peptide Biol, La Jolla, CA 92037 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2002年 / 188卷 / 1-2期

关键词：

D O I：

10.1016/S0303-7207(02)00037-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Activin and inhibin research has provided important insight into reproductive physiology as well as many areas involving regulation of cell growth, differentiation and function. Progress in understanding the roles of these hormones in various cell and tissue types has been complimented by novel discoveries at the molecular level that have shed light on ligand/receptor interactions, signaling mechanisms and regulation. While the receptors and signaling pathway for activin are now well characterized, the molecular basis for inhibin action has remained relatively unclear. Here we summarize recent advances in understanding inhibin's mode of action focusing on our recent identification of betaglycan as an inhibin co-receptor capable of mediating inhibin action. 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：253 / 260

页数：8

共 90 条

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