Benzophenone Derivatives from the Fruits of Garcinia multiflora and Their Anti-inflammatory Activity

被引：60

作者：

Chen, Jih-Jung ^{[1
]}

Ting, Chia-Wei ^{[1
]}

Hwang, Tsong-Long ^{[2
]}

Chen, Ih-Sheng ^{[3
]}

机构：

[1] Tajen Univ, Grad Inst Pharmaceut Technol, Pingtung 907, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[3] Kaohsiung Med Univ, Coll Pharm, Grad Inst Phannaceut Sci, Kaohsiung 807, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 02期

关键词：

CYTOTOXIC XANTHONES; CONSTITUENTS; SUBELLIPTICA; PHLOROGLUCINOLS; SUPEROXIDE; TERPENOIDS; BIPHENYLS; LINII; ROOT;

D O I：

10.1021/np8006364

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Five new benzophenone derivatives, 13,14-didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), 13-hydroxygarcimultiflorone B (4), and garcimultiflorone C (5), have been isolated froth the fruits of Garcinia multiflora, together with seven known compounds (6-12). The structures of these new compounds were determined through spectroscopic and MS analyses. 13,14-Didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), and 13-hdroxygarcimultiflorone B (4) exhibited Inhibition with an IC(50) range of 0.11-5.58 mu M on superoxide anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B (fMLP/CB).

引用

页码：253 / 258

页数：6

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