Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp Tu 6075 -: I.: Taxonomy, fermentation, isolation and biological activities

被引：124

作者：

Schimana, J

Gebhardt, K

Höltzel, A

Schmid, DG

Süssmuth, R

Müller, J

Pukall, R

Fiedler, HP

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

[3] Deutsch Sammlung Mikroorganismen & Zellkulturen, D-38124 Braunschweig, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 06期

关键词：

D O I：

10.7164/antibiotics.55.565

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New lipopeptide antibiotics, colourless arylomycins A series and yellow arylomycins B series were detected in the culture filtrate and mycelium extracts of Streptomyces sp. Tu 6075 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. Arylomycins are a family of lipohexapeptide antibiotics, which represent the first examples of biaryl-bridged lipopeptides. They show antibiotic activities against Gram-positive bacteria.

引用

页码：565 / 570

页数：6

共 14 条

[1]

[Anonymous], 1991, inNucleic Acid Techniques in Bacterial Systematics

[2]

[Anonymous], 1993, NAT PROD LETT

[3] Bagremycin A and B, novel antibiotics from Streptomyces sp Tu 4128 [J].