Tirucallane triterpenes from Dysoxylum macranthum

被引：40

作者：

Mohamad, K ^{[1
]}

Martin, MT ^{[1
]}

Litaudon, M ^{[1
]}

Gaspard, C ^{[1
]}

Sévenet, T ^{[1
]}

Païs, M ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

PHYTOCHEMISTRY | 1999年 / 52卷 / 08期

关键词：

Dysoxylum macranthum; Meliaceae; tirucallane triterpenoids; structural elucidation;

D O I：

10.1016/S0031-9422(99)00455-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eleven new tirucallane-type triterpenes, dymacrins A-K, were isolated from the bark of Dysoxylum macranthum together with two known tetracyclic triterpenes and two known pregnane steroids. The structures of the new compounds were determined by spectral means, essentially 2D NMR experiments. Dymacrins B, C, H and J showed moderate cytotoxicity against KB cells (IC50 5.6, 5.0, 8.3 and 1.0 mu g/ml, respectively). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1461 / 1468

页数：8

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