Primary peripheral PNET/Ewing's sarcoma of the dura: a clinicopathologic entity distinct from central PNET

被引：72

作者：

Dedeurwaerdere, F

Giannini, C

Sciot, R

Rubin, BP

Perilongo, G

Borghi, L

Ballotta, ML

Cornips, E

Demunter, A

Maes, B

Tos, APD

机构：

[1] Katholieke Univ Leuven, Dept Pathol, Louvain, Belgium

[2] Mayo Clin, Dept Pathol, Rochester, MN USA

[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[4] Univ Padua, Sch Med, Div Pediat Oncol, Padua, Italy

[5] Hosp Rovigo, Dept Pathol, Rovigo, Italy

[6] Acad Ziekenhuis Maastricht, Dept Neurosurg, Maastricht, Netherlands

[7] Reg Hosp Treviso, Dept Pathol, Treviso, Italy

来源：

MODERN PATHOLOGY | 2002年 / 15卷 / 06期

关键词：

CD99; Ewing's sarcoma; meninges; peripheral primitive neuroectodermal tumor; t(11; 22);

D O I：

10.1038/modpathol.3880585

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We describe two cases of peripheral primitive neuroectodermal tumor-Ewing's sarcoma (PNET-ES) arising intracranially in the leptomeninges. Both tumors exhibited a primitive undifferentiated round-cell morphology. Immunohistochemical stains revealed strong membrane expression of CD99 in both cases. A t(11;22)(q24;q12) could be demonstrated with reverse transcriptase-polymerase chain reaction in one case, whereas fluorescence in situ hybridization analysis performed in the second case showed a rearrangement of the EWS gene. The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET.

引用

页码：673 / 678

页数：6