Pentasaccharides

被引：10

作者：

Turpie, AGG ^{[1
]}

机构：

[1] Hamilton Gen Hosp, Hamilton Hlth Sci, Hamilton, ON L8L 2X2, Canada

来源：

SEMINARS IN HEMATOLOGY | 2002年 / 39卷 / 03期

关键词：

D O I：

10.1053/shem.2002.34091

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fondaparinux sodium is the first in a new class of antithrombotic agents possessing selective inhibitory activity against factor Xa. The agent was designed and developed with the objective of overcoming the limitations of currently available therapies for the prevention and treatment of venous and arterial thromboembolic disease. Extensive data from preclinical and clinical trials demonstrate fondaparinux's favorable pharmacokinetic profile combined with promising efficacy and safety results in the prevention of venous thromboembolism following major orthopedic surgery, in the tréatment of deep venous thrombosis, and in acute coronary syndromes. Copyright 2002, Elsevier Science (USA). All rights reserved.

引用

页码：158 / 171

页数：14

共 45 条

[21]

LAGRANGE F, IN PRESS THROMB HAEM

[22]

LASSEN MR, IN PRESS LANCET

[23]

Lormeau JC, 1995, THROMB HAEMOSTASIS, V74, P1474

[24]

MESSMORE HL, 1989, ANN NY ACAD SCI, V556, P217

[25] Heparin-induced thrombocytopenia: Historical review [J].

Messmore, HL .

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 1999, 5 :S2-S6

[26]

OLLENDORF D, 2000, AM SOC HLTH SYST PHA

[27]

OLSON ST, 1992, J BIOL CHEM, V267, P12528

[28]

PAOLUCCI F, IN PRESS CLIN PHAR S

[29]

*PENT TRIAL, 2001, 74 SCI SESS AM HEART

[30] BINDING OF HEPARIN TO ANTITHROMBIN-III - A CHEMICAL PROOF OF THE CRITICAL ROLE PLAYED BY A 3-SULFATED 2-AMINO-2-DEOXY-D-GLUCOSE RESIDUE [J].

PETITOU, M ;

DUCHAUSSOY, P ;

LEDERMAN, I ;

CHOAY, J ;

SINAY, P .

CARBOHYDRATE RESEARCH, 1988, 179 :163-172

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