Synergistic tumor promoter effects of estrone and progesterone in methylnitrosourea-induced rat mammary cancer

被引：16

作者：

Bigsby, RA ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Obstet & Gynecol, Indianapolis, IN 46202 USA

来源：

CANCER LETTERS | 2002年 / 179卷 / 02期

关键词：

estrogen; progesterone; methylnitrosourea; rat; mammary tumorigenesis;

D O I：

10.1016/S0304-3835(02)00032-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor promoter effects of steroid hormones were tested in ovariectomized rats treated with the tumor initiator, methylnitrosourea. Continuous treatment with low doses of estrone induced tumor in 55% of experimental animals while intact control animals had a 96-100% incidence. Although progesterone alone produced no tumors in ovariectomized, methylnitrosourea-treated animals, estrone and progesterone acted synergistically, inducing tumorigenesis in 88% of treated rats. These results point to an important interaction between estrogens and progestins in promoting mammary tumorigenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：113 / 119

页数：7

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