Synergistic tumor promoter effects of estrone and progesterone in methylnitrosourea-induced rat mammary cancer

被引：16

作者：

Bigsby, RA ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Obstet & Gynecol, Indianapolis, IN 46202 USA

来源：

CANCER LETTERS | 2002年 / 179卷 / 02期

关键词：

estrogen; progesterone; methylnitrosourea; rat; mammary tumorigenesis;

D O I：

10.1016/S0304-3835(02)00032-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor promoter effects of steroid hormones were tested in ovariectomized rats treated with the tumor initiator, methylnitrosourea. Continuous treatment with low doses of estrone induced tumor in 55% of experimental animals while intact control animals had a 96-100% incidence. Although progesterone alone produced no tumors in ovariectomized, methylnitrosourea-treated animals, estrone and progesterone acted synergistically, inducing tumorigenesis in 88% of treated rats. These results point to an important interaction between estrogens and progestins in promoting mammary tumorigenesis. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：113 / 119

页数：7

共 45 条

[31] Short-term exposure to pregnancy levels of estrogen prevents mammary carcinogenesis [J].

Rajkumar, L ;

Guzman, RC ;

Yang, J ;

Thordarson, G ;

Talamantes, F ;

Nandi, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) :11755-11759

[32] Effect of hormone replacement therapy on breast cancer risk: Estrogen versus estrogen plus progestin [J].

Ross, RK ;

Paganini-Hill, A ;

Wan, PC ;

Pike, MC .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (04) :328-332

[33]

RUSSO J, 1990, LAB INVEST, V62, P244

[34] Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk [J].

Schairer, C ;

Lubin, J ;

Troisi, R ;

Sturgeon, S ;

Brinton, L ;

Hoover, R .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (04) :485-491

[35]

SCHNEIDER MR, 1990, ANTICANCER RES, V10, P683

[36] Impact of progesterone receptor on cell-fate decisions during mammary gland development [J].

Shyamala, G ;

Yang, X ;

Cardiff, RD ;

Dale, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3044-3049

[37] ESSENTIAL ROLE OF ENDOGENOUS ESTROGEN IN DIRECTLY STIMULATING MAMMARY GROWTH DEMONSTRATED BY IMPLANTS CONTAINING PURE ANTIESTROGENS [J].

SILBERSTEIN, GB ;

VANHORN, K ;

SHYAMALA, G ;

DANIEL, CW .

ENDOCRINOLOGY, 1994, 134 (01) :84-90

[38] Hormone-induced refractoriness to mammary, carcinogenesis in Wistar-Furth rats [J].

Sivaraman, L ;

Stephens, L ;

Markaverich, BM ;

Clark, JA ;

Krnacik, S ;

Conneely, OM ;

O'Malley, BW ;

Medina, D .

CARCINOGENESIS, 1998, 19 (09) :1573-1581

[39] EXOGENOUS PROGESTINS AND BREAST-CANCER [J].

STANFORD, JL ;

THOMAS, DB .

EPIDEMIOLOGIC REVIEWS, 1993, 15 (01) :98-107

[40] The xenoestrogen bisphenol A induces growth, differentiation, and c-fos gene expression in the female reproductive tract [J].

Steinmetz, R ;

Mitchner, NA ;

Grant, A ;

Allen, DL ;

Bigsby, RM ;

Ben-Jonathan, N .

ENDOCRINOLOGY, 1998, 139 (06) :2741-2747

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