Mitochondria and cancer: is there a morphological connection?

被引：125

作者：

Alirol, E. ^{[1
]}

Martinou, J. C. ^{[1
]}

机构：

[1] Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

来源：

ONCOGENE | 2006年 / 25卷 / 34期

关键词：

mitochondrial morphology; apoptosis; energy metabolism; cancer;

D O I：

10.1038/sj.onc.1209600

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are key players in several cellular functions including growth, division, energy metabolism, and apoptosis. The mitochondrial network undergoes constant remodelling and these morphological changes are of direct relevance for the role of this organelle in cell physiology. Mitochondrial dysfunction contributes to a number of human disorders and may aid cancer progression. Here, we summarize the recent contributions made in the field of mitochondrial dynamics and discuss their impact on our understanding of cell function and tumorigenesis.

引用

页码：4706 / 4716

页数：11

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