Articular cartilage nuclear receptors: an emerging target for treatment of osteoarthritis

被引：14

作者：

Loeser, R. F. ^{[1
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Sect Mol Med, Dept Internal Med, Winston Salem, NC 27157 USA

来源：

OSTEOARTHRITIS AND CARTILAGE | 2009年 / 17卷 / 07期

关键词：

Cartilage; Osteoarthritis; Nuclear receptors; Therapy; METALLOPROTEINASE GENE-EXPRESSION; THERAPEUTIC TARGETS; GAMMA AGONIST; X-RECEPTOR; VITAMIN-D; CHONDROCYTES; PIOGLITAZONE; PROGRESSION; DISEASE; ALPHA;

D O I：

10.1016/j.joca.2009.03.025

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

引用

页码：829 / 831

页数：3

共 22 条

[1]

Integration of metabolism and inflammation by lipid-activated nuclear receptors [J].

Bensinger, Steven J. ;

Tontonoz, Peter .

NATURE, 2008, 454 (7203) :470-477

[2]

The peroxisome proliferator-activated receptor γ agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis [J].

Boileau, Christelle ;

Martel-Pelletier, Johanne ;

Fahmi, Hassan ;

Mineau, Francois ;

Boily, Martin ;

Pelletier, Jean-Pierre .

ARTHRITIS AND RHEUMATISM, 2007, 56 (07) :2288-2298

[3]

Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) α and γ and retinoid Z receptor in cartilage -: PPARγ activation modulates the effects of interleukin-1β on rat chondrocytes [J].

Bordji, K ;

Grillasca, JP ;

Gouze, JN ;

Magdalou, J ;

Schohn, H ;

Keller, JM ;

Bianchi, A ;

Dauça, M ;

Netter, P ;

Terlain, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (16) :12243-12250

[4]

Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression [J].

Burrage, Peter S. ;

Schmucker, Adam C. ;

Ren, Yanqing ;

Sporn, Michael B. ;

Brinckerhoff, Constance E. .

ARTHRITIS RESEARCH & THERAPY, 2008, 10 (06)

[5]

Functional characterization of an orphan nuclear receptor, Rev-ErbAa, in chondrocytes and its potential role in steoarthritis [J].

Chaturvedi, P. ;

Pratta, M. ;

Steplewski, K. ;

Connor, J. ;

Kumar, S. .

ARTHRITIS AND RHEUMATISM, 2006, 54 (11) :3513-3522

[6]

Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage Reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis [J].

Collins-Racie, L. A. ;

Yang, Z. ;

Arai, M. ;

Li, N. ;

Majumdar, M. K. ;

Nagpal, S. ;

Mounts, W. M. ;

Dorner, A. J. ;

Morris, E. ;

LaVallie, E. R. .

OSTEOARTHRITIS AND CARTILAGE, 2009, 17 (07) :832-842

[7]

A composite element binding the vitamin D receptor and the retinoic X receptor α mediates the transforming growth factor-β inhibition of decorin gene expression in articular chondrocytes [J].

Demoor-Fossard, M ;

Galéra, P ;

Santra, M ;

Iozzo, RV ;

Pujol, JP ;

Rédini, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (40) :36983-36992

[8]

Fahmi H, 2001, ARTHRITIS RHEUM, V44, P595, DOI 10.1002/1529-0131(200103)44:3<595::AID-ANR108>3.0.CO

[9]

2-8

[10]

Osteoarthritis [J].

Goldring, Mary B. ;

Goldring, Steven R. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 213 (03) :626-634

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