Enantioseparation of fourteen O-ethyl O-phenyl N-isopropyl phosphoroamidothioates by high-performance liquid chromatography on a chiral stationary phase

A series of fourteen O-ethyl O-phenyl N-isopropyl phosphoroamidothioate enantiomers containing a phosphorus atom as a chiral center have been separated by high-performance liquid chromatography on a Pirkle model chiral stationary phase. Chromatography data, the capacity factor (k') and the separation factor (alpha) of all solutes are presented. The influence of chromatographic conditions was investigated. The probable mechanism for chiral recognition is proposed.