Gain of function mutagenesis of the erythromycin polyketide synthase .2. Engineered biosynthesis of eight-membered ring tetraketide lactone

被引：74

作者：

Kao, CM

McPherson, M

McDaniel, RN

Fu, H

Cane, DE

Khosla, C

机构：

[1] STANFORD UNIV,DEPT CHEM ENGN,STANFORD,CA 94305

[2] STANFORD UNIV,DEPT CHEM & BIOCHEM,STANFORD,CA 94305

[3] BROWN UNIV,DEPT CHEM,PROVIDENCE,RI 02912

[4] KOSAN BIOSCI INC,BURLINGAME,CA 94010

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1997年 / 119卷 / 46期

关键词：

D O I：

10.1021/ja972609e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：11339 / 11340

页数：2

共 25 条

[1] A functional chimeric modular polyketide synthase generated via domain replacement
Bedford, D
Jacobsen, JR
Luo, GL
Cane, DE
Khosla, C
[J]. CHEMISTRY & BIOLOGY, 1996, 3 (10): : 827 - 831
[2] REPOSITIONING OF A DOMAIN IN A MODULAR POLYKETIDE SYNTHASE TO PROMOTE SPECIFIC CHAIN CLEAVAGE
CORTES, J
WIESMANN, KEH
ROBERTS, GA
BROWN, MJB
STAUNTON, J
LEADLAY, PF
[J]. SCIENCE, 1995, 268 (5216) : 1487 - 1489
[3] ORGANIZATION OF THE ENZYMATIC DOMAINS IN THE MULTIFUNCTIONAL POLYKETIDE SYNTHASE INVOLVED IN ERYTHROMYCIN FORMATION IN SACCHAROPOLYSPORA-ERYTHRAEA
DONADIO, S
KATZ, L
[J]. GENE, 1992, 111 (01) : 51 - 60
[4] AN ERYTHROMYCIN ANALOG PRODUCED BY REPROGRAMMING OF POLYKETIDE SYNTHESIS
DONADIO, S
MCALPINE, JB
SHELDON, PJ
JACKSON, M
KATZ, L
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) : 7119 - 7123
[5] MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS
DONADIO, S
STAVER, MJ
MCALPINE, JB
SWANSON, SJ
KATZ, L
[J]. SCIENCE, 1991, 252 (5006) : 675 - 679
[6] BIOSYNTHESIS OF THE ERYTHROMYCIN MACROLACTONE AND A RATIONAL APPROACH FOR PRODUCING HYBRID MACROLIDES
DONADIO, S
STAVER, MJ
MCALPINE, JB
SWANSON, SJ
KATZ, L
[J]. GENE, 1992, 115 (1-2) : 97 - 103
[7] GOKHALE RS, UNPUB
[8] Hopwood D.A., 1985, GENETIC MANIPULATION
[9] RING-CLOSURE REACTIONS OF BIFUNCTIONAL CHAIN MOLECULES
ILLUMINATI, G
MANDOLINI, L
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1981, 14 (04) : 95 - 102
[10] Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase
Jacobsen, JR
Hutchinson, CR
Cane, DE
Khosla, C
[J]. SCIENCE, 1997, 277 (5324) : 367 - 369

← 1 2 3 →