Diastereoselective synthesis of α-oxyamines via gold-, silver- and copper-catalyzed, three-component couplings of α-oxyaldehydes, alkynes, and amines in water

被引：112

作者：

Huang, Baosheng

Yao, Xiaoquan

Li, Chao-Jun ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Appl Chem Res Inst, Beijing, Peoples R China

[2] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2006年 / 348卷 / 12-13期

关键词：

alkynes; amines; gold-catalyzed; alpha-oxyaldehydes; reaction in water; three-component coupling;

D O I：

10.1002/adsc.200606118

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The three-component couplings of alpha-oxyaldehydes, alkynes, and amines in water were investigated by using gold, silver and copper catalysts. Gold(I) was found to be the most effective catalyst in this reaction to afford propargylamines in good yields and moderate diastereoselectivities. On the other hand, silver catalysts show the best catalytic activities on non-coordinating a-alkyl-substituted aldehydes.

引用

页码：1528 / 1532

页数：5

共 39 条

[1] HYDROPHOBIC EFFECTS ON SIMPLE ORGANIC-REACTIONS IN WATER [J].