Selectively substituted thiophenes and indoles by a tandem palladium-catalyzed multicomponent reaction

被引：75

作者：

Mitsudo, Koichi ^{[1
]}

Thansandote, Praew ^{[1
]}

Wilhelm, Thorsten ^{[1
]}

Mariampillai, Brian ^{[1
]}

Lautens, Mark ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 18期

关键词：

D O I：

10.1021/ol061373t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of di- and trisubstituted thiophenes were synthesized by a one-pot palladium- catalyzed ortho-alkylation sequence terminated by either Heck or C-H coupling. Initial results toward the functionalization of indoles are also presented.

引用

页码：3939 / 3942

页数：4

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