An experimental and theoretical study of mass transfer from loaded embolisation microbeads: Possible optimisation

被引：12

作者：

Amyot, F ^{[1
]}

Jurski, K ^{[1
]}

Dufaux, J ^{[1
]}

Guiffant, G ^{[1
]}

机构：

[1] Univ Paris 07, Lab Biorheol & Hydrodynam Physicochim, CNRS, ESA 7057, F-75251 Paris, France

来源：

INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER | 2002年 / 29卷 / 05期

关键词：

D O I：

10.1016/S0735-1933(02)00381-0

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The development of loaded galenical formulations requires specific tests leading to a sharp discrimination of kinetics release. We have presented an experimental protocol where particular hydrodynamic conditions are implemented, permitting the drug to be transported by a controlled diffusive-convective process, after chemical liberation from the microbeads. This study shows that the procedure leads to satisfactory results regarding the characterization of closely related galenical formulations. A two dimensional phenomenological approach leads to the promising possibility of optimizing the procedure. (C) 2002 Elsevier Science Ltd.

引用

页码：623 / 632

页数：10

共 17 条

[1] Three-dimensional centrifugal-flow instabilities in the lid-driven-cavity problem [J].

Albensoeder, S ;

Kuhlmann, HC ;

Rath, HJ .

PHYSICS OF FLUIDS, 2001, 13 (01) :121-135

[2] Lid-driven cavity with heat and mass transport [J].

Alleborn, N ;

Raszillier, H ;

Durst, F .

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 1999, 42 (05) :833-853

[3]

AMYOT F, 2000, 5 S WORKSH PHARM THE

[4]

Beaujeux R, 1996, AM J NEURORADIOL, V17, P541

[5]

BEAUJEUX R, 1991, NEURORADIOLOGY S, V33, P562

[6] THERMAL-ANALYSIS FOR A COMPOSITE WALL HAVING ONE SURFACE SUBJECT TO A CRENELATED VARIATION OF THE AMBIENT-TEMPERATURE [J].

DUHAMEL, P ;

GOSSE, J .

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 1980, 23 (12) :1663-1671

[7] Two-dimensional vortex motions of fluid in harbor-like basins at large Reynolds numbers [J].

Goncharov, VP ;

Pavlov, VI .

PHYSICS OF FLUIDS, 1998, 10 (09) :2384-2395

[8]

GOSSE J, 1978, CR ACAD SCI B PHYS, V286, P303

[9] THE USE OF THE WALSH-FUNCTIONS FOR THE STUDY OF PERIODIC DIFFUSIVE PHENOMENA IN A MULTILAYER MEDIUM [J].

GUIFFANT, G ;

ARHALIASS, A ;

DUFAUX, J .

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 1988, 31 (09) :1952-1954

[10]

Laurent A, 1996, AM J NEURORADIOL, V17, P533

← 1 2 →