An experimental and theoretical study of mass transfer from loaded embolisation microbeads: Possible optimisation

被引：12

作者：

Amyot, F ^{[1
]}

Jurski, K ^{[1
]}

Dufaux, J ^{[1
]}

Guiffant, G ^{[1
]}

机构：

[1] Univ Paris 07, Lab Biorheol & Hydrodynam Physicochim, CNRS, ESA 7057, F-75251 Paris, France

来源：

INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER | 2002年 / 29卷 / 05期

关键词：

D O I：

10.1016/S0735-1933(02)00381-0

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The development of loaded galenical formulations requires specific tests leading to a sharp discrimination of kinetics release. We have presented an experimental protocol where particular hydrodynamic conditions are implemented, permitting the drug to be transported by a controlled diffusive-convective process, after chemical liberation from the microbeads. This study shows that the procedure leads to satisfactory results regarding the characterization of closely related galenical formulations. A two dimensional phenomenological approach leads to the promising possibility of optimizing the procedure. (C) 2002 Elsevier Science Ltd.

引用

页码：623 / 632

页数：10

共 17 条

[11]

LEVY M, 1994, INT J PHARM, V66, P29

[12] Fluid mixing and mass transfer enhancement in grooved channels for pulsatile flow [J].

Nishimura, T ;

Kunitsugu, K ;

Morega, AM .

JOURNAL OF ENHANCED HEAT TRANSFER, 1998, 5 (01) :23-+

[13] Evaluation and comparison of dissolution data derived from different modified release dosage forms: an alternative method [J].

Pillay, V ;

Fassihi, R .

JOURNAL OF CONTROLLED RELEASE, 1998, 55 (01) :45-55

[14] Three-dimensional Stokes flow in a cylindrical container [J].

Shankar, PN .

PHYSICS OF FLUIDS, 1998, 10 (03) :540-549

[15] Computational simulations of vorticity enhanced diffusion [J].

Vold, EL .

PHYSICS OF FLUIDS, 1999, 11 (11) :3353-3368

[16]

WASHINGTON C, 1990, J PHARM, V58, P69

[17] Permeability and diffusion in vitreous humor: Implications for drug delivery [J].

Xu, J ;

Heys, JJ ;

Barocas, VH ;

Randolph, TW .

PHARMACEUTICAL RESEARCH, 2000, 17 (06) :664-669

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