Computational Analysis of mRNA Expression Profiles Identifies the ITG Family and PIK3R3 as Crucial Genes for Regulating Triple Negative Breast Cancer Cell Migration

被引：17

作者：

Klahan, Sukhontip ^{[1
]}

Wu, Mei-Shin ^{[1
]}

Hsi, Edward ^{[2
]}

Huang, Chi-Cheng ^{[3
,4
,5
,6
]}

Hou, Ming-Feng ^{[7
,8
,9
]}

Chang, Wei-Chiao ^{[1
,7
,10
,11
]}

机构：

[1] Taipei Med Univ, Dept Clin Pharm, Taipei 110, Taiwan

[2] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807, Taiwan

[3] Natl Taiwan Univ, Grad Inst Biomed Elect & Bioinformat, Taipei 106, Taiwan

[4] Cathay Gen Hosp SiJhih, New Taipei 221, Taiwan

[5] Fu Jen Catholic Univ, Sch Med, New Taipei 242, Taiwan

[6] Taipei Med Univ, Sch Med, Taipei 110, Taiwan

[7] Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung 807, Taiwan

[8] Kaohsiung Med Univ Hosp, Dept Surg, Kaohsiung 807, Taiwan

[9] Kaohsiung Municipal Tatung Hosp, Kaohsiung 801, Taiwan

[10] Taipei Med Univ, Wan Fang Hosp, Dept Pharm, Taipei 116, Taiwan

[11] Taipei Med Univ, Sch Pharm, Master Program Clin Pharmacogen & Pharmacoprote, Taipei 110, Taiwan

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

HEPATOCYTE GROWTH-FACTOR; DISTANT METASTASIS; PATTERNS; MELANOMA; INVASION; FEATURES; TARGET;

D O I：

10.1155/2014/536591

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (Her2/neu). TNBC has worse clinical outcomes than other breast cancer subtypes. However, the key molecules and mechanisms of TNBC migration remain unclear. In this study, we compared two normalized microarray datasets from GEO database between Asian (GSE33926) and non-Asian populations (GSE46581) to determine the molecules and common pathways in TNBC migration. We demonstrated that 16 genes in non-Asian samples and 9 genes in Asian samples are related to TNBC migration. In addition, our analytic results showed that 4 genes, PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton. Our results indicated potential genes that link to TNBC migration. This study may help identify novel therapeutic targets for drug development in cancer therapy.

引用

页数：8

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