Engineered and designed peptide-based fibrous biomaterials

被引：123

作者：

MacPhee, CE

Woolfson, DN

机构：

[1] Univ Sussex, Sch Life Sci, Ctr Biomol Design & Drug Dev, Brighton BN1 9QG, E Sussex, England

[2] Univ Cambridge, Cavendish Lab, Dept Phys, Cambridge CB3 0HE, England

来源：

CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE | 2004年 / 8卷 / 02期

关键词：

alpha-helix; amyloid fibril; beta-sheet; coiled coil; fibre; nanotechnology; peptide; protein; protein design;

D O I：

10.1016/j.cossms.2004.01.010

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Our increasing understanding of peptide and protein folding and assembly raises new possibilities for engineering novel self-assembling supramolecular structures and bio-inspired materials. Here we focus on peptides designed de novo, and natural systems that have been engineered to form extended protein fibres. Potential applications of such assemblies include the preparation of functionalised biomaterials for the development of new diagnostic devices, scaffolds to recruit cells for cell/tissue engineering, and templates for the assembly of inorganic materials. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：141 / 149

页数：9

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