Multiwavelength Photoacoustic Imaging and Plasmon Resonance Coupling of Gold Nanoparticles for Selective Detection of Cancer

被引：361

作者：

Mallidi, Srivalleesha ^{[1
]}

Larson, Timothy ^{[1
]}

Tam, Justina ^{[1
]}

Joshi, Pratixa P. ^{[1
]}

Karpiouk, Andrei ^{[1
]}

Sokolov, Konstantin ^{[1
,2
]}

Emelianov, Stanislav ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77030 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 08期

基金：

美国国家卫生研究院;

关键词：

INTRACLASS CORRELATION-COEFFICIENT; IN-VIVO; CONTRAST AGENT; PHOTOTHERMAL THERAPY; OPTICAL-PROPERTIES; HUMAN SKIN; TISSUES; NANOTECHNOLOGY; TOMOGRAPHY; ANTIBODIES;

D O I：

10.1021/nl802929u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticles targeting epidermal growth factor receptor via antibody conjugation undergo molecular specific aggregation when they bind to receptors on cell surfaces, leading to a red shift in their plasmon resonance frequency. Capitalizing on this effect, we demonstrate the efficacy of the molecular specific photoacoustic imaging technique using subcutaneous tumor-mimicking gelatin implants in ex-vivo mouse tissue. The results of our study suggest that highly selective and sensitive detection of cancer cells is possible using multiwavelength photoacoustic imaging and molecular specific gold nanoparticles.

引用

页码：2825 / 2831

页数：7

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