Relationship of atypical melatonin rhythm with two circadian clock outputs in B6D2F1 mice

被引:27
作者
Li, XM
Liu, XH
Filipski, E
Metzger, G
Delagrange, P
Jeanniot, JP
Lévi, F
机构
[1] ICIG, Lab Rythms Biol & Chronotherapeut, F-94807 Villejuif, France
[2] Univ Paris 11, Hop Paul Brousse, F-94807 Villejuif, France
[3] Inst Rech Int Servier, F-92415 Courbevoie, France
[4] Technol Servier, F-45000 Orleans, France
关键词
circadian rhythms; body temperature; locomotor activity; pineal gland;
D O I
10.1152/ajpregu.2000.278.4.R924
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Circadian rhythms in body temperature, locomotor activity, and the circadian changes of plasma and pineal melatonin content were investigated in B6D2F(1) mice synchronized by 12 h of light and 12 h of darkness. During 8 wk continuous recording, activity and temperature displayed a marked stable and reproducible circadian rhythm, with both peaks occurring near the middle of darkness. Both 24-and 12-h rhythmic components were also significantly detected. Mean plasma melatonin concentration rose steadily during the light span and reached a maximum (30.6 +/- 10.0 pg/ml) at 11 h after light onset (HALO), then gradually decreased after the onset of darkness to a nadir (4.7 +/- 0.4 pg/ml) at 20 HALO. Mean pineal content followed a pattern parallel to that of plasma concentration (peak at 11 HALO: 17.7 +/-: 1.0 pg/gland; trough at 17 HALO: 4.7 +/- 1.0 pg/gland). In addition, a second sharp peak was observed at 21 HALO (20.2 +/-: 3.5 pg/gland). Plasma and pineal contents displayed large and statistically significant circadian changes, with a composite rhythm of period (24 + 12 h). This mouse model has predominant production and secretion of melatonin during the day. This possibly contributes to a similar coupling between chronopharmacology mechanisms and the rest-activity cycle in these mice and in human subjects.
引用
收藏
页码:R924 / R930
页数:7
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