Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction

被引：1075

作者：

Haigis, Marcia C. ^{[1
]}

Guarente, Leonard P. ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

GENES & DEVELOPMENT | 2006年 / 20卷 / 21期

关键词：

Sir2; aging; glutamate dehydrogenase; SIRT1-7; mitochondria; insulin; calorie restriction;

D O I：

10.1101/gad.1467506

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging.

引用

页码：2913 / 2921

页数：9

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