Association of BCL10 germ line polymorphisms on chromosome 1p with advanced stage testicular germ cell tumor patients

被引：4

作者：

Inoue, Takamitsu

Ito, Takuo

Narita, Shintaro

Horikawa, Yohei

Tsuchiya, Norihiko

Kakinuma, Hideaki

Mishina, Mutsuki

Nakamura, Eijiro

Kato, Tetsuro

Ogawa, Osamu

Habuchi, Tomonori

机构：

[1] Akita Univ, Sch Med, Dept Urol, Akita 0108543, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Urol, Sakyo Ku, Kyoto 6068507, Japan

来源：

CANCER LETTERS | 2006年 / 240卷 / 01期

关键词：

BCL10; polymorphism; testicular germ cell tumor;

D O I：

10.1016/j.canlet.2005.08.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The association between four BCL10 single nucleotide polymorphisms at codons 5, 8, 162, and intron 1 and the susceptibility or progression for germ cell tumors (GCTs) was investigated in 73 testicular GCT patients and 72 controls. GCT patients with metastatic disease were more likely to have a variant type allele of the polymorphisms at codon 5 (age-adjusted odds ratio (aCR) = 6.25; 95% CI = 1.09-35.83; P = 0.040) and codon 8 (aOR = 4.63; 95% CI = 1.35-15.93; P = 0.015) than those with the localized disease. Therefore, BCL10 polymorphisms at codons 5 and 8 may play a role in the progression to advanced stage GCTs. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：41 / 47

页数：7

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