Inflammatory bowel disease and environmental influences

被引:25
作者
Krishnan, A
Korzenik, JR
机构
[1] Washington Univ, Sch Med, Div Gastroenterol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
关键词
D O I
10.1016/S0889-8553(01)00003-6
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The dramatic emergence of IBD over the past century, particularly in the industrialized countries of Europe and North America, implicates a strong environmental influence in the development of Crohn's disease and ulcerative colitis. An extensive array of factors has been investigated, ranging from diet and tobacco to occupation and toothpaste. In recent years, the peculiar relationship between smoking and IBD has been clarified with divergent influences in the two diseases: protective in ulcerative colitis, while harmful in Crohn's disease. New research has established appendectomy as a potent protective factor against the development of ulcerative colitis. Numerous other issues, such as breast feeding, sanitation, oral contraceptives, and refined sugar intake, remain less well defined and controversial. This article summarizes the extensive investigation of complex interactions between the environment and IBD.
引用
收藏
页码:21 / +
页数:20
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共 138 条
[31]  
GLASSMAN MS, 1990, AM J GASTROENTEROL, V85, P838
[32]   METAANALYSIS OF THE ROLE OF ORAL-CONTRACEPTIVE AGENTS IN INFLAMMATORY BOWEL-DISEASE [J].
GODET, PG ;
MAY, GR ;
SUTHERLAND, LR .
GUT, 1995, 37 (05) :668-673
[33]   STUDIES OF PROSTAGLANDINS AND SULPHASALAZINE IN ULCERATIVE-COLITIS [J].
GOULD, SR ;
BRASH, AR ;
CONOLLY, ME ;
LENNARDJONES, JE .
PROSTAGLANDINS AND MEDICINE, 1981, 6 (02) :165-182
[34]   INFLUENCE OF INTRAVENOUS N-3 LIPID SUPPLEMENTATION ON FATTY-ACID PROFILES AND LIPID MEDIATOR GENERATION IN A PATIENT WITH SEVERE ULCERATIVE-COLITIS [J].
GRIMMINGER, F ;
FUHRER, D ;
PAPAVASSILIS, C ;
SCHLOTZER, E ;
MAYER, K ;
HEUER, KU ;
KISS, L ;
WALMRATH, D ;
PIBERHOFER, S ;
LUBBECKE, F ;
KRAMER, HJ ;
STEVENS, J ;
SCHUTTERLE, G ;
SEEGER, W .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1993, 23 (11) :706-715
[35]  
GYDE SN, 1984, Q J MED, V53, P351
[36]   SMOKING-HABITS AND INFLAMMATORY BOWEL-DISEASE - EFFECT ON NUTRITION [J].
HARRIES, AD ;
JONES, L ;
HEATLEY, RV ;
RHODES, J .
BRITISH MEDICAL JOURNAL, 1982, 284 (6323) :1161-1161
[37]   NONSMOKING - A FEATURE OF ULCERATIVE-COLITIS [J].
HARRIES, AD ;
BAIRD, A ;
RHODES, J .
BRITISH MEDICAL JOURNAL, 1982, 284 (6317) :706-706
[38]   Measles, month of birth, and Crohn's disease [J].
Haslam, N ;
Mayberry, JF ;
Hawthorne, AB ;
Newcombe, RG ;
Holmes, GKT ;
Probert, CSJ .
GUT, 2000, 47 (06) :801-803
[39]   MESENTERIC LYMPHATIC OBSTRUCTION IN CROHNS-DISEASE [J].
HEATLEY, RV ;
BOLTON, PM ;
HUGHES, LE ;
OWEN, EW .
DIGESTION, 1980, 20 (05) :307-313
[40]  
HECKERS H, 1988, Z GASTROENTEROL, V26, P259