Effect of clarithromycin on chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation in an experimental murine model

被引：48

作者：

Yanagihara, K ^{[1
]}

Tomono, K ^{[1
]}

Imamura, Y ^{[1
]}

Kaneko, Y ^{[1
]}

Kuroki, M ^{[1
]}

Sawai, T ^{[1
]}

Miyazaki, Y ^{[1
]}

Hirakata, Y ^{[1
]}

Mukae, H ^{[1
]}

Kadota, JI ^{[1
]}

Kohno, S ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 852, Japan

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2002年 / 49卷 / 05期

关键词：

macrolide antibiotics; chronic respiratory infection; Pseudomonas aeruginosa; biofilm formation; murine model;

D O I：

10.1093/jac/dkf013

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Fourteen-membered macrolides (e.g. clarithromycin and erythromycin), but not 16-membered macrolides (e.g. josamycin), are effective in diffuse panbronchiolitis. However, there are no studies that have compared the effects of 14- and 16-membered macrolide antibiotics on biofilm formation. Treatment with high-dose clarithromycin (100 mg/kg) resulted in a significant decrease in the number of viable bacteria in an experimental murine model. Josamycin at a dose of up to 100 mg/kg had no effect on the number of viable bacteria in the lung. Our results may explain, at least in part, the clinical efficacy of 14-membered macrolide antibiotics in patients with chronic pneumonia caused by Pseudomonas aeruginosa.

引用

页码：867 / 870

页数：4

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