Snake venom thrombin-like enzymes: from reptilase to now

被引：143

作者：

Castro, HC

Zingali, RB

Albuquerque, MG

Pujol-Luz, M

Rodrigues, CR

机构：

[1] Univ Fed Fluminense, IBCEG, Dept Biol Celular & Mol, Lab Bioquim & Modelagem Mol, BR-24001970 Niteroi, RJ, Brazil

[2] Univ Fed Rio de Janeiro, ICBCCS, Dept Bioquim Med, Lab Hemostase & Veneno, BR-21941590 Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, IQCCMN, Dept Quim Organ, Lab Modelagem Mol, BR-21949900 Rio De Janeiro, Brazil

[4] Univ Fed Rio de Janeiro, Fac Farm, Lab Modelagem Mol & QSAR, BR-21941590 Rio De Janeiro, Brazil

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2004年 / 61卷 / 7-8期

关键词：

snake venom; thrombin; fibrinogen; platelets; primary sequence; serine protease;

D O I：

10.1007/s00018-003-3325-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The snake venom thrombin-like enzymes (SVTLEs) comprise a number of serine proteases functionally and structurally related to thrombin. Until recently, only nine complete sequences of this subgroup of the serine protease family were known. Over the past 5 years, the primary structure of several SVTLEs has been characterized, and now this family includes several members. Of particular interest is their possible use in pathologies such as thrombosis. The aim of the present review is to summarize the state of the art concerning the evolutionary, structural and biological features of the SVTLEs.

引用

页码：843 / 856

页数：14

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