Accessing Genetic Information with Liquid Biopsies

被引：164

作者：

Cai, Xuyu ^{[1
]}

Janku, Filip ^{[2
]}

Zhan, Qimin ^{[3
,4
]}

Fan, Jian-Bing ^{[1
]}

机构：

[1] Illumina Inc, Oncol, San Diego, CA 92122 USA

[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[3] Chinese Acad Med Sci, State Key Lab Mol Oncol, Beijing 100021, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

来源：

TRENDS IN GENETICS | 2015年 / 31卷 / 10期

基金：

美国国家卫生研究院;

关键词：

CIRCULATING TUMOR-CELLS; METASTATIC BREAST-CANCER; COPY NUMBER ABERRATIONS; COLORECTAL-CANCER; FREE DNA; NONINVASIVE DETECTION; RARE MUTATIONS; BRAF MUTATIONS; BIOMARKERS; PLASMA;

D O I：

10.1016/j.tig.2015.06.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Recent scientific advances in understanding circulating tumor cells, cell-free DNA/RNA, and exosomes in blood have laid a solid foundation for the development of routine molecular 'liquid biopsies'. This approach provides non-invasive access to genetic information - somatic mutations, epigenetic changes, and differential expression - about the physiological conditions of our body and diseases. It opens a valuable avenue for future genetic studies and human disease diagnosis, including prenatal and neurodegenerative disease diagnosis, as well as for cancer screening and monitoring. With the rapid development of highly sensitive and accurate technologies such as next-generation sequencing, molecular 'liquid biopsies' will quickly become a central piece in the future of precision medicine.

引用

页码：564 / 575

页数：12

共 70 条

[1]

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].

Aceto, Nicola ;

Bardia, Aditya ;

Miyamoto, David T. ;

Donaldson, Maria C. ;

Wittner, Ben S. ;

Spencer, Joel A. ;

Yu, Min ;

Pely, Adam ;

Engstrom, Amanda ;

Zhu, Huili ;

Brannigan, Brian W. ;

Kapur, Ravi ;

Stott, Shannon L. ;

Shioda, Toshi ;

Ramaswamy, Sridhar ;

Ting, David T. ;

Lin, Charles P. ;

Toner, Mehmet ;

Haber, Daniel A. ;

Maheswaran, Shyamala .

CELL, 2014, 158 (05) :1110-1122

[2]

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay [J].

Baccelli, Irene ;

Schneeweiss, Andreas ;

Riethdorf, Sabine ;

Stenzinger, Albrecht ;

Schillert, Anja ;

Vogel, Vanessa ;

Klein, Corinna ;

Saini, Massimo ;

Baeuerle, Tobias ;

Wallwiener, Markus ;

Holland-Letz, Tim ;

Hoefner, Thomas ;

Sprick, Martin ;

Scharpff, Martina ;

Marme, Frederik ;

Sinn, Hans Peter ;

Pantel, Klaus ;

Weichert, Wilko ;

Trumpp, Andreas .

NATURE BIOTECHNOLOGY, 2013, 31 (06) :539-U143

[3]

Whole-genome methylation analysis of benign and malignant colorectal tumours [J].

Beggs, Andrew D. ;

Jones, Angela ;

El-Bahwary, Mona ;

Abulafi, Muti ;

Hodgson, Shirley V. ;

Tomlinson, Ian P. M. .

JOURNAL OF PATHOLOGY, 2013, 229 (05) :697-704

[4]

Non-invasive prenatal testing for aneuploidy: current status and future prospects [J].

Benn, P. ;

Cuckle, H. ;

Pergament, E. .

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2013, 42 (01) :15-33

[5]

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[6]

High density DNA methylation array with single CpG site resolution [J].

Bibikova, Marina ;

Barnes, Bret ;

Tsan, Chan ;

Ho, Vincent ;

Klotzle, Brandy ;

Le, Jennie M. ;

Delano, David ;

Zhang, Lu ;

Schroth, Gary P. ;

Gunderson, Kevin L. ;

Fan, Jian-Bing ;

Shen, Richard .

GENOMICS, 2011, 98 (04) :288-295

[7]

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data [J].

Bidard, Francois-Clement ;

Peeters, Dieter J. ;

Fehm, Tanja ;

Nole, Franco ;

Gisbert-Criado, Rafael ;

Mavroudis, Dimitrios ;

Grisanti, Salvatore ;

Generali, Daniele ;

Garcia-Saenz, Jose A. ;

Stebbing, Justin ;

Caldas, Carlos ;

Gazzaniga, Paola ;

Manso, Luis ;

Zamarchi, Rita ;

Fernandez de Lascoiti, Angela ;

De Mattos-Arruda, Leticia ;

Ignatiadis, Michail ;

Lebofsky, Ronald ;

van Laere, Steven J. ;

Meier-Stiegen, Franziska ;

Sandri, Maria-Teresa ;

Vidal-Martinez, Jose ;

Politaki, Eleni ;

Consoli, Francesca ;

Bottini, Alberto ;

Diaz-Rubio, Eduardo ;

Krell, Jonathan ;

Dawson, Sarah-Jane ;

Raimondi, Cristina ;

Rutten, Annemie ;

Janni, Wolfgang ;

Munzone, Elisabetta ;

Caranana, Vicente ;

Agelaki, Sofi A. ;

Almici, Camillo ;

Dirix, Luc ;

Solomayer, Erich-Franz ;

Zorzino, Laura ;

Johannes, Helene ;

Reis-Filho, Jorge S. ;

Pantel, Klaus ;

Pierga, Jean-Yves ;

Michiels, Stefan .

LANCET ONCOLOGY, 2014, 15 (04) :406-414

[8]

Going with the Flow: From Circulating Tumor Cells to DNA [J].

Bidard, Francois-Clement ;

Weigelt, Britta ;

Reis-Filho, Jorge S. .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (207)

[9]

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer [J].

Board, Ruth E. ;

Wardley, Andrew M. ;

Dixon, J. Michael ;

Armstrong, Anne C. ;

Howell, Sacha ;

Renshaw, Lorna ;

Donald, Emma ;

Greystoke, Alastair ;

Ranson, Malcolm ;

Hughes, Andrew ;

Dive, Caroline .

BREAST CANCER RESEARCH AND TREATMENT, 2010, 120 (02) :461-467

[10]

Campan Mihhaela, 2009, V507, P325, DOI 10.1007/978-1-59745-522-0_23

← 1 2 3 4 5 6 7 →