Going with the Flow: From Circulating Tumor Cells to DNA

被引：106

作者：

Bidard, Francois-Clement ^{[1
,2
]}

Weigelt, Britta ^{[1
]}

Reis-Filho, Jorge S. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA

[2] Inst Curie, Dept Med Oncol, F-75005 Paris, France

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2013年 / 5卷 / 207期

关键词：

BREAST-CANCER PATIENTS; GENETIC-HETEROGENEITY; MUTATIONAL EVOLUTION; ACQUIRED-RESISTANCE; COLORECTAL-CANCER; PERIPHERAL-BLOOD; METASTATIC SITES; PROSTATE-CANCER; RARE MUTATIONS; PLASMA;

D O I：

10.1126/scitranslmed.3006305

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Molecular analyses of circulating tumor DNA (ctDNA) in plasma from cancer patients have the potential to deliver minimally invasive diagnostic and disease-monitoring biomarkers. Drawing from experience gained through the translation of circulating-tumor cell detection to clinical tests, we discuss ctDNA as a source of tumor material for biomarker development.

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