Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins

被引:16
作者
Martin, LJ
Cianflone, K
Zakarian, R
Nagrani, G
Almasy, L
Rainwater, DL
Cole, S
Hixson, JE
MacCluer, JW
Blangero, J
Comuzzie, AG
机构
[1] Childrens Hosp, Med Ctr, Ctr Biostat & Epidemiol, Cincinnati, OH 45229 USA
[2] SW Fdn Biomed Res, San Antonio, TX 78284 USA
[3] McGill Univ, MUHC, Mike Rosenbloom Lab Cardiovasc Dis, Montreal, PQ, Canada
[4] Univ Texas, Hlth Sci Ctr, Houston, TX USA
来源
OBESITY RESEARCH | 2004年 / 12卷 / 04期
关键词
acylation-stimulating protein; bivariate linkage analysis; adipokines; Mexican Americans; C3adesArg;
D O I
10.1038/oby.2004.77
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Given the importance of visceral adiposity in the metabolic syndrome, whether levels of adipokines have shared genetic effects (pleiotropy) with aspects of the metabolic syndrome should be addressed. Acylation-stimulating protein (ASP), an adipose-derived protein, influences lipid metabolism, obesity, and glucose use. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects. Research Methods and Procedures: We assayed serum ASP levels in 435 Mexican Americans participating in the San Antonio Family Heart Study and performed univariate and bivariate variance components analysis. Results: Additive genetic heritability of ASP was 26% (p=0.0004). Bivariate genetic analysis detected significant genetic correlations between ASP and several lipid measures but not between ASP and adiposity or diabetes measures. We detected two potential quantitative trait loci influencing ASP levels. The strongest signal was on chromosome 17 near marker D17S1303 [log of the odds ratio (LOD)=2.7]. The signal on chromosome 15 reached its peak near marker D15S641 (LOD=2.1). Both signals localize in regions reported to harbor quantitative trait loci influencing obesity and lipid phenotypes in this population. Bivariate linkage analysis yielded LODs of 4.7 for ASP and BMI on chromosome 17 and 3.2 for ASP and high-density lipoprotein,a on chromosome 15. Discussion: Given these findings, there seems to be a significant genetic contribution to variation in circulating levels of ASP and an interesting pattern of genetic correlation (i.e., pleiotropy) with other risk factors associated with the metabolic syndrome.
引用
收藏
页码:669 / 678
页数:10
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