Emerging cancer therapeutic opportunities target DNA-repair systems

被引：116

作者：

Ding, Jian ^{[1
]}

Miao, Ze-Hong ^{[1
]}

Meng, Ling-Hua ^{[1
]}

Geng, Mei-Yu ^{[1
]}

机构：

[1] Chinese Acad Sci, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai Inst Mat Med,Inst Biol Sci, Shanghai 201203, Peoples R China

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2006年 / 27卷 / 06期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.tips.2006.04.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

DNA-damaging agents have a central role in nonsurgical cancer treatment. The balance between DNA damage and repair determines the final therapeutic consequences. An elevated DNA-repair capacity in tumor cells leads to drug or radiation resistance and severely limits the efficacy of these agents. Interference with DNA repair has emerged as an important approach in combination therapy against cancer. Anticancer targets in DNA-repair systems have emerged, against which several small-molecule compounds are currently undergoing clinical trials.

引用

页码：338 / 344

页数：7

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