Synthesis and antibacterial activity of novel bifunctional macrolides

被引：10

作者：

Akritopoulou-Zanze, I ^{[1
]}

Phelan, KM ^{[1
]}

Marron, TG ^{[1
]}

Yong, H ^{[1
]}

Ma, ZK ^{[1
]}

Stone, GG ^{[1
]}

Daly, MM ^{[1
]}

Hensey, DM ^{[1
]}

Nilius, AM ^{[1
]}

Djuric, SW ^{[1
]}

机构：

[1] Global Pharmaceut Res & Dev, Abbott Labs, Lake Bluff, IL 60044 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 14期

关键词：

bifunctional macrolides; macrolide resistance; ketolides;

D O I：

10.1016/j.bmcl.2004.04.077

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：3809 / 3813

页数：5

共 12 条

[1] Synthesis and antibacterial activity of ketolides (6-O-methyl-3-oxoerythromycin derivatives):: A new class of antibacterials highly potent against macrolide-resistant and -susceptible respiratory pathogens [J].

Agouridas, C ;

Denis, A ;

Auger, JM ;

Benedetti, Y ;

Bonnefoy, A ;

Bretin, F ;

Chantot, JF ;

Dussarat, A ;

Fromentin, C ;

D'Ambrières, SG ;

Lachaud, S ;

Laurin, P ;

Le Martret, O ;

Loyau, V ;

Tessot, N .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (21) :4080-4100

[2] Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA [J].

Douthwaite, S ;

Hansen, LH ;

Mauvais, P .

MOLECULAR MICROBIOLOGY, 2000, 36 (01) :183-192

[3] Macrolide antibiotics: Binding site, mechanism of action, resistance [J].

Gaynor, M ;

Mankin, AS .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2003, 3 (09) :949-960

[4] Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit [J].

Hansen, JL ;

Moore, PB ;

Steitz, TA .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 330 (05) :1061-1075

[5] Replacing the nucleohases in DNA with designer molecules [J].

Kool, ET .

ACCOUNTS OF CHEMICAL RESEARCH, 2002, 35 (11) :936-943

[6] Regioselective synthesis of bifunctional macrolides for probing ribosomal binding [J].

Ma, ZK ;

Li, LP ;

Rupp, M ;

Zhang, SM ;

Zhang, XL .

ORGANIC LETTERS, 2002, 4 (06) :987-990

[7]

*NAT COMM CLIN LAB, 1997, M7A4 NAT COMM CLIN L

[8] Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens [J].

Or, YS ;

Clark, RF ;

Wang, SY ;

Chu, DTW ;

Nilius, AM ;

Flamm, RK ;

Mitten, M ;

Ewing, P ;

Alder, J ;

Ma, ZK .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (06) :1045-1049

[9]

Poehlsgaard Jacob, 2003, Curr Opin Investig Drugs, V4, P140

[10]

Poehlsgaard Jacob, 2002, Current Drug Targets - Infectious Disorders, V2, P67, DOI 10.2174/1568005024605927

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