Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives

被引：28

作者：

Tomson, T.

Luef, G.

Sabers, A.

Pittschieler, S.

Ohman, I.

机构：

[1] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[2] Karolinska Inst, Dept Clin Pharmacol, Stockholm, Sweden

[3] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria

[4] Glostrup Univ Hosp, Dept Neurol, Glostrup, Denmark

来源：

NEUROLOGY | 2006年 / 67卷 / 07期

关键词：

PHARMACOKINETICS;

D O I：

10.1212/01.wnl.0000238522.79277.9c

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In eight women treated with lamotrigine monotherapy, the lamotrigine dose/plasma concentration (D/C) ratio increased by 295% from baseline outside pregnancy to midgestation, whereas in six women treated with lamotrigine in combination with valproate, the increase was only 60%. No difference in lamotrigine D/C ratio was found between users and nonusers of oral contraceptives comedicated with valproate. Valproate seems to reduce the induction of lamotrigine metabolism associated with pregnancy or use of contraceptives.

引用

收藏

页码：1297 / 1299

页数：3

相关论文

共 10 条

[1] Lamotrigine and the risk of malformations in pregnancy [J].

Cunnington, M ;

Tennis, P .

NEUROLOGY, 2005, 64 (06) :955-960

[2] Gestation-induced changes in lamotrigine pharmacokinetics:: A monotherapy study [J].

de Haan, GJ ;

Edelbroek, P ;

Segers, J ;

Engelsman, M ;

Lindhout, D ;

Dévilé-Notschaele, M ;

Augustijn, P .

NEUROLOGY, 2004, 63 (03) :571-573

[3] Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy [J].

Gidal, BE ;

Anderson, GD ;

Rutecki, PR ;

Shaw, R ;

Lanning, A .

EPILEPSY RESEARCH, 2000, 42 (01) :23-31

[4] Drug glucuronidation in clinical psychopharmacology [J].

Liston, HL ;

Markowitz, JS ;

DeVane, CL .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2001, 21 (05) :500-515

[5] Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register [J].

Morrow, J ;

Russell, A ;

Guthrie, E ;

Parsons, L ;

Robertson, I ;

Waddell, R ;

Irwin, B ;

McGivern, RC ;

Morrison, PJ ;

Craig, J .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2006, 77 (02) :193-198

[6] Lamotrigine in pregnancy: Pharmacokinetics during delivery, in the neonate, and during lactation [J].

Ohman, I ;

Vitols, S ;

Tomson, T .

EPILEPSIA, 2000, 41 (06) :709-713

[7] Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs [J].

Patsalos, PN ;

Perucca, E .

LANCET NEUROLOGY, 2003, 2 (06) :347-356

[8] The impact of pregnancy and childbirth on the metabolism of lamotrigine [J].

Pennell, PB ;

Newport, DJ ;

Stowe, ZN ;

Helmers, SL ;

Montgomery, JQ ;

Henry, TR .

NEUROLOGY, 2004, 62 (02) :292-295

[9] Oral contraceptives reduce lamotrigine plasma levels [J].

Sabers, A ;

Öhman, I ;

Christensen, J ;

Tomson, T .

NEUROLOGY, 2003, 61 (04) :570-571

[10] Lamotrigine clearance during pregnancy [J].

Tran, TA ;

Leppik, IE ;

Blesi, K ;

Sathanandan, ST ;

Remmel, R .

NEUROLOGY, 2002, 59 (02) :251-255