Mechanisms of neuroprotective action of vitamin D3

被引：91

作者：

Kalueff, AV

Eremin, KO

Tuohimaa, P

机构：

[1] Ctr Physiol & Biochem Res, UA-01042 Kiev, Ukraine

[2] Russian Acad Med Sci, Inst Pharmacol, Moscow 125315, Russia

[3] Univ Tampere, Sch Med, Dept Clin Chem, Tampere 33014, Finland

来源：

BIOCHEMISTRY-MOSCOW | 2004年 / 69卷 / 07期

关键词：

vitamin D-3; calcitriol; nervous system; neuroprotection;

D O I：

10.1023/B:BIRY.0000040196.65686.2f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review considers modem data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D-3 and its receptors in the nervous system. Special attention is paid to Ca2+ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main biologically active form of vitamin D3, in the nervous system.

引用

页码：738 / 741

页数：4

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