Memory T cells need CD28 costimulation to remember

被引：99

作者：

Boesteanu, Alina C. ^{[1
]}

Katsikis, Peter D. ^{[1
]}

机构：

[1] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19129 USA

来源：

SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 02期

关键词：

Costimulation; Memory; CD4+T cells; CD8+T cells; CD28; ENDOTHELIAL GROWTH-FACTOR; B7; FAMILY-MEMBER; DENDRITIC CELLS; CUTTING EDGE; IN-VITRO; ANTIGEN PRESENTATION; ANTITUMOR IMMUNITY; INFLUENZA-VIRUS; TUMOR; EXPRESSION;

D O I：

10.1016/j.smim.2009.02.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activation and expansion of naive T cells require costimulatory signals provided by CD28 and TNF family members. In contrast, for many years it was believed that memory T cells do not require CD28 costimulation for expansion during secondary responses. This was based on in vitro experiments that suggested the re-activation of memory T cells is somewhat independent of costimulation. Recent in vivo evidence, however, has challenged this and shown that both CD4+ and CD8+ memory T cells require CD28 costimulation for maximal expansion and pathogen clearance. This requirement has important implications for host immunity, vaccine development and immunotherapeutics. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：69 / 77

页数：9