Opinion - Non-inherited antibiotic resistance

被引:394
作者
Levin, Bruce R. [1 ]
Rozen, Daniel E. [1 ]
机构
[1] Emory Univ, Dept Biol, Atlanta, GA 30307 USA
基金
英国惠康基金;
关键词
D O I
10.1038/nrmicro1445
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In addition to their impressive, well-publicized and well-researched propensity to evolve and acquire genetically determined mechanisms for resistance to antibiotics, bacteria that are inherently susceptible to these drugs can also be phenotypically refractory to their action. This phenomenon of 'non-inherited resistance' to antibiotics has been known since the beginning of the antibiotic era but, relative to inherited resistance, it has been given little attention. Here, we review the in vitro and in vivo evidence for the different forms of non-inherited resistance and the mechanisms responsible. With the aid of a simple mathematical model and computer simulations, we show how non-inherited resistance could extend the duration of antibiotic treatment, cause treatment failure and promote the generation and ascent of inherited resistance in treated patients.
引用
收藏
页码:556 / 562
页数:7
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