Schizophrenia and red light: fMRI evidence for a novel biobehavioral marker

被引：21

作者：

Bedwell, Jeffrey S.

Miller, L. Stephen

Brown, James M.

Yanasak, Nathan E.

机构：

[1] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA

[2] Univ Georgia, Dept Psychol, Athens, GA 30602 USA

[3] Med Coll Georgia, Sch Med, Dept Radiol, Augusta, GA 30912 USA

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2006年 / 116卷 / 08期

关键词：

biobehavioral marker; endophenotype; first-degree relatives; functional magnetic resonance imaging; magnocellular visual pathway; red light;

D O I：

10.1080/00207450500516529

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous research has demonstrated the ability of diffuse red light to suppress activity in the magnocellular (M) visual pathway. An earlier psychophysical study found that a subset of nonpsychotic relatives of persons with schizophrenia showed the opposite effect when compared to healthy adults (Bedwell et al., 2003), suggesting a novel biobehavioral marker for the disorder. The present study attempted to replicate and explore the mechanism for this effect using fMRI. Results provide physiological evidence that the M pathway response to red light is in the opposite direction than expected in a subset of nonpsychotic relatives of persons with schizophrenia.

引用

收藏

页码：881 / 894

页数：14

相关论文

共 38 条

[1] Elementary phenotypes in the neurobiological and genetic study of schizophrenia [J].

Adler, LE ;

Freedman, R ;

Ross, RG ;

Olincy, A ;

Waldo, MC .

BIOLOGICAL PSYCHIATRY, 1999, 46 (01) :8-18

[2] Spatiotemporal activity of a cortical network for processing visual motion revealed by MEG and fMRI [J].

Ahlfors, SP ;

Simpson, GV ;

Dale, AM ;

Belliveau, JW ;

Liu, AK ;

Korvenoja, A ;

Virtanen, J ;

Huotilainen, M ;

Tootell, RBH ;

Aronen, HJ ;

Ilmoniemi, RJ .

JOURNAL OF NEUROPHYSIOLOGY, 1999, 82 (05) :2545-2555

[3] Functional MRI of lateral occipitotemporal cortex during pursuit and motion perception [J].

Barton, JJS ;

Simpson, T ;

Kiriakopoulos, E ;

Stewart, C ;

Crawley, A ;

Guthrie, B ;

Wood, M ;

Mikulis, D .

ANNALS OF NEUROLOGY, 1996, 40 (03) :387-398

[4] Functional magnetic resonance imaging examination of the magnocellular visual pathway in nonpsychotic relatives of persons with schizophrenia [J].

Bedwell, JS ;

Miller, LS ;

Brown, JM ;

McDowell, JE ;

Yanasak, NE .

SCHIZOPHRENIA RESEARCH, 2004, 71 (2-3) :509-510

[5] The magnocellular visual system and schizophrenia: what can the color red tell us? [J].

Bedwell, JS ;

Brown, JM ;

Miller, LS .

SCHIZOPHRENIA RESEARCH, 2003, 63 (03) :273-284

[6] Sensory information processing in neuroleptic-naive first-episode schizophrenic patients -: A functional magnetic resonance imaging study [J].

Braus, DF ;

Weber-Fahr, W ;

Tost, H ;

Ruf, M ;

Henn, FA .

ARCHIVES OF GENERAL PSYCHIATRY, 2002, 59 (08) :696-701

[7] EFFECTS OF ISOLUMINANT-BACKGROUND COLOR ON METACONTRAST AND STROBOSCOPIC MOTION - INTERACTIONS BETWEEN SUSTAINED (P) AND TRANSIENT (M) CHANNELS [J].

BREITMEYER, BG ;

WILLIAMS, MC .

VISION RESEARCH, 1990, 30 (07) :1069-1075

[8] EFFECTS OF BACKGROUND COLOR ON REACTION-TIME TO STIMULI VARYING IN SIZE AND CONTRAST - INFERENCES ABOUT HUMAN M-CHANNELS [J].

BREITMEYER, BG ;

BREIER, JI .

VISION RESEARCH, 1994, 34 (08) :1039-1045

[9] IMPLICATIONS OF SUSTAINED AND TRANSIENT CHANNELS FOR THEORIES OF VISUAL-PATTERN MASKING, SACCADIC SUPPRESSION, AND INFORMATION-PROCESSING [J].

BREITMEYER, BG ;

GANZ, L .

PSYCHOLOGICAL REVIEW, 1976, 83 (01) :1-36

[10] Influences of occlusion, color, and luminance on the perception of fragmented pictures [J].

Brown, JM ;

Koch, C .

PERCEPTUAL AND MOTOR SKILLS, 2000, 90 (03) :1033-1044

← 1 2 3 4 →