High serum level of soluble CD30 in acute primary HIV-1 infection

被引：53

作者：

Pizzolo, G

Vinante, F

Nadali, G

Krampera, M

Morosato, L

Chilosi, M

机构：

[1] UNIV VERONA,POLICLIN BORGO ROMA,SCH MED,DEPT HAEMATOL,I-37134 VERONA,ITALY

[2] UNIV VERONA,POLICLIN BORGO ROMA,SCH MED,DEPT PATHOL,I-37134 VERONA,ITALY

[3] UNIV TURIN,SCH MED,INST INFECT DIS,TURIN,ITALY

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1997年 / 108卷 / 02期

关键词：

CD30; soluble CD30; acute HIV-1 infection;

D O I：

10.1046/j.1365-2249.1997.d01-1005.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD30 has been suggested to play a role in HIV infection. In this study the serum concentration of soluble CD30 (sCD30) was determined by an ELISA essay on samples collected from patients with acute primary HIV-1 infection during the acute phase (n = 17) and after seroconversion (n = 13). sCD30 during acute infection was consistently elevated (137.58 +/- 120.33 versus 6.4 +/- 5.4 U/ml (mean +/- s.d.) in normal controls; P<0.0001) and decreased after seroconversion (49.1 +/- 66.17 U/ml; P = 0.0018 compared with acute infection). This trend mirrored the disappearance of detectable levels of HIV antigen in the blood, resulting in a direct correlation between sCD30 and HIVAg values (P = 0.002). These data suggest that the high levels of sCD30 observed during the peak concentration of HIVAg in acute primary HIV infection might reflect the high rate of viral replication.

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页码：251 / 253

页数：3

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