Chorioamnionitis in the Pathogenesis of Brain Injury in Preterm Infants

被引：55

作者：

Chau, Vann ^{[1
,3
,4
]}

McFadden, Deborah E. ^{[4
,5
,6
,7
,8
]}

Poskitt, Kenneth J. ^{[4
,6
,7
,8
,9
,10
]}

Miller, Steven P. ^{[1
,2
,3
,4
]}

机构：

[1] Hosp Sick Children, Dept Pediat, Div Neurol, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Res Inst, Neurosci & Mental Hlth Program, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Dept Pediat, Toronto, ON M5S 2J7, Canada

[4] Child & Family Res Inst, Vancouver, BC V5Z 4H4, Canada

[5] BC Childrens & Womens Hlth Ctr, Dept Pathol, Vancouver, BC V6H 3V4, Canada

[6] Univ British Columbia, Dept Pediat, Vancouver, BC V6T 1Z4, Canada

[7] Univ British Columbia, Dept Pathol, Vancouver, BC V6T 1Z4, Canada

[8] Univ British Columbia, Dept Radiol, Vancouver, BC V6T 1Z4, Canada

[9] BC Childrens & Womens Hlth Ctr, Dept Pediat, Vancouver, BC V6H 3V4, Canada

[10] BC Childrens & Womens Hlth Ctr, Dept Radiol, Vancouver, BC V6H 3V4, Canada

来源：

CLINICS IN PERINATOLOGY | 2014年 / 41卷 / 01期

关键词：

Placental infection; White matter injury; Neurodevelopment; Cerebral palsy; Magnetic resonance imaging; Diffusion tensor imaging; Magnetic resonance spectroscopic imaging; FETAL INFLAMMATORY RESPONSE; BIRTH-WEIGHT INFANTS; NECROSIS-FACTOR-ALPHA; CHRONIC LUNG-DISEASE; WHITE-MATTER INJURY; AMNIOTIC-FLUID CYTOKINES; CEREBRAL-PALSY; HISTOLOGICAL CHORIOAMNIONITIS; INTRAVENTRICULAR HEMORRHAGE; NECROTIZING ENTEROCOLITIS;

D O I：

10.1016/j.clp.2013.10.009

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Chorioamnionitis (or placental infection) is suspected to be a risk factor for brain injury in premature infants. The suggested association between chorioamnionitis and cystic periventricular leukomalacia and cerebral palsy is uncertain because of the variability of study designs and definitions of chorioamnionitis. Improvements in neonatal intensive care may have attenuated the impact of chorioamnionitis on brain health outcomes. Large multicenter studies using rigorous definitions of chorioamnionitis on placental pathologies and quantitative magnetic resonance techniques may offer the optimal way to clarify the complex role of chorioamnionitis in modifying brain health and long-term outcomes.

引用

页码：83 / +

页数：22

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