Naringin suppresses the development of glioblastoma by inhibiting FAK activity

被引：29

作者：

Li, Jinjiang ^{[1
]}

Dong, Yushu ^{[1
]}

Hao, Guangzhi ^{[1
]}

Wang, Bao ^{[2
]}

Wang, Julei ^{[2
]}

Liang, Yong ^{[1
]}

Liu, Yangyang ^{[1
]}

Zhen, Endi ^{[1
]}

Feng, Dayun ^{[2
]}

Liang, Guobiao ^{[1
]}

机构：

[1] Shenyang Mil Area Command, Gen Hosp, Inst Neurol, 83 Wenhua Rd, Shenyang, Liaoning, Peoples R China

[2] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian, Shaanxi, Peoples R China

来源：

JOURNAL OF DRUG TARGETING | 2017年 / 25卷 / 01期

关键词：

FAK; glioblastoma; metastasis; naringin; proliferation; FOCAL ADHESION KINASE; CANCER-CELLS; MATRIX METALLOPROTEINASES; SIGNALING PATHWAY; TUMOR-GROWTH; EXPRESSION; PROTEIN; GLIOMA; GENES; TEMOZOLOMIDE;

D O I：

10.1080/1061186X.2016.1184668

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

As the most common and lethal primary malignant brain cancer, glioblastoma is hard to timely diagnose and sensitive therapeutic monitoring. It is essential to develop new and effective drugs for glioblastoma multiform. Naringin belongs to citrus flavonoids and was found to display strong anti-inflammatory, antioxidant and antitumor activities. In this report, we found that naringin can specifically inhibit the kinase activity of FAK and suppress the FAK(p-Try397)and its downstream pathway in glioblastoma cells. Our study showed out that naringin can inhibit cell proliferation by inhibiting FAK/cyclin D1 pathway, promote cell apoptosis through influencing FAK/bads pathway, at the same time, it can also inhibit cell invasion and metastasis by inhibiting the FAK/mmps pathway. All these showed that naringin exerts the anti-tumor effects in U87MG by inhibiting the kinase activity of FAK.

引用

页码：41 / 48

页数：8

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