Interaction of Aldosterone and Extracellular Volume in the Pathogenesis of Obesity-Associated Kidney Disease: A Narrative Review

被引：36

作者：

Bomback, Andrew S. ^{[1
]}

Klemmer, Philip J. ^{[1
]}

机构：

[1] Univ N Carolina, Kidney Ctr, Dept Med, Div Nephrol & Hypertens, Chapel Hill, NC 27599 USA

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 2009年 / 30卷 / 02期

关键词：

Aldosterone; Extracellular volume; Obesity; Chronic kidney disease; BODY-MASS INDEX; INITIATED METABOLIC SYNDROME; STAGE RENAL-DISEASE; PLASMA-ALDOSTERONE; UNITED-STATES; HYPERTENSIVE PATIENTS; WEIGHT-LOSS; GLOMERULAR HYPERFILTRATION; MINERALOCORTICOID RECEPTOR; RESISTANT HYPERTENSION;

D O I：

10.1159/000209744

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity and obesity-associated kidney injuries have played an important role in the rising prevalence of chronic kidney disease (CKD). The link between obesity and kidney disease begins with obesity's well-known associations with diabetes and hypertension, the two leading etiologies of CKD. However, a growing body of evidence suggests that elevated aldosterone levels and expanded extracellular volume are key components of obesity-induced renal disease via aldosterone's non-epithelial effects on the kidney. Highlighting these blood pressure- and diabetes-independent mechanisms of kidney injury in obesity allows an exploration of whether mineralocorticoid receptor blockade, coupled with weight loss and salt restriction, is an optimal treatment for overweight CKD patients. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：140 / 146

页数：7

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