Quantitative Trait Locus Mapping Can Benefit From Segregation Distortion

被引:153
作者
Xu, Shizhong [1 ]
机构
[1] Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA
基金
美国国家科学基金会;
关键词
D O I
10.1534/genetics.108.090688
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Segregation distortion is a phenomenon that has been observed in many experimental systems. How segregation distortion among markers arises and its impact on mapping Studies are the focus of this work. Segregation distortion of markers can be considered to arise from segregation distortion loci (SDL). I develop a theory of segregation distortion and show that the presence of only a few SDL can cause the entire chromosome to distort from Mendelian segregation. Segregation distortion is detrimental to the power of detecting quantitative trait loci (QTL) with dominance effects, but it is not always a detriment to QTL mapping for additive effects. When segregation distortion of a locus is a random event, tire SDL is beneficial to QTL mapping similar to 44% of the time. If SDL are present and ignored, power loss can be substantial. A dense marker map can be used to ameliorate the situation, and if dense marker information is incorporated, power loss is minimal. However, other situations are less benign. A method that can Simultaneously map QTL and SDL is discussed, maximizing both rise of mapping resources and use by agricultural and evolutionary biologists.
引用
收藏
页码:2201 / 2208
页数:8
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