Behavioral effects of somatostatin microinjected into caudate putamen

被引：12

作者：

Tashev, R ^{[1
]}

Belcheva, S ^{[1
]}

Milenov, K ^{[1
]}

Belcheva, I ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Physiol, Lab Expt Psychopharmacol, BU-1113 Sofia, Bulgaria

来源：

NEUROPEPTIDES | 2001年 / 35卷 / 5-6期

关键词：

D O I：

10.1054/npep.2001.0872

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present study examined the behavioral responses to bilateral microinjections of somatostatin (SRIF) into caudate putamen of male Wistar rats. SRIF locally administered at doses of 10, 50 and 100 ng/side dose-dependently affected locomotor activity, as reflected in both horizontal and vertical movements. SRIF modulated locomotor activity in a biphasic manner, exerting an inhibitory and a facilitatory effect. In the elevated plus-maze experiments, SRIF at doses of 50 and 100 ng/side microinjected bilaterally into cauclate putamen decreased only the total number of entries in the open and closed maze arms, confirming the suppressing effect of SRIF on locomotion at the first 5 min. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：271 / 275

页数：5

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