Behavioral effects of angiotensin II microinjected into CA1 hippocampal area

被引：27

作者：

Belcheva, I ^{[1
]}

Georgiev, V ^{[1
]}

Chobanova, M ^{[1
]}

Hadjiivanova, C ^{[1
]}

机构：

[1] BULGARIAN ACAD SCI,INST PHYSIOL,LAB EXPT PSYCHOPHARMACOL,BU-1113 SOFIA,BULGARIA

来源：

NEUROPEPTIDES | 1997年 / 31卷 / 01期

关键词：

D O I：

10.1016/S0143-4179(97)90021-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The behavioral responses of rats to bilateral microinjections of angiotensin II (ATII) at doses of 0.1, 0.5 and 1.0 mu g into the hippocampal CA1 area of male Sprague-Dawley rats were studied. ATII affected locomotor activity (the number of horizontal and vertical movements) in a dose-related U-shaped manner. In the elevated plus-maze experiments, ATII at a dose of 0.1 mu g microinjected bilaterally into the CAI hippocampal area increased the number of entries into the open arms, suggesting some anxiolytic effect.

引用

页码：60 / 64

页数：5

共 19 条

[1]

BRASZKO J, 1976, POL J PHARMACOL PHAR, V28, P667

[2] ANGIOTENSIN-II AND ITS 3-7 FRAGMENT IMPROVE RECOGNITION BUT NOT SPATIAL MEMORY IN RATS [J].

BRASZKO, JJ ;

KULAKOWSKA, A ;

WISNIEWSKI, K .

BRAIN RESEARCH BULLETIN, 1995, 37 (06) :627-631

[3] BEHAVIORAL-EFFECTS OF ANGIOTENSIN-II AND ANGIOTENSIN-II-(4-8)-PENTAPEPTIDE IN RATS [J].

BRASZKO, JJ ;

WLASIENKO, J ;

KUPRYSZEWSKI, G ;

WITCZUK, B ;

WISNIEWSKI, K .

PHYSIOLOGY & BEHAVIOR, 1988, 44 (03) :327-332

[4] EFFECT OF ANGIOTENSIN-II AND SARALASIN ON MOTOR-ACTIVITY AND THE PASSIVE-AVOIDANCE BEHAVIOR OF RATS [J].

BRASZKO, JJ ;

WISNIEWSKI, K .

PEPTIDES, 1988, 9 (03) :475-479

[5] THE RENIN-ANGIOTENSIN SYSTEM IN THE BRAIN - AN UPDATE 1993 [J].

BUNNEMANN, B ;

FUXE, K ;

GANTEN, D .

REGULATORY PEPTIDES, 1993, 46 (03) :487-509

[6]

GEORGIEV V, 1987, METHOD FIND EXP CLIN, V9, P297

[7]

GEORGIEV V, 1990, POL J PHARMACOL PHAR, V42, P553

[8]

HOHLE S, 1995, PHARMACOL TOXICOL, V77, P306

[9] IMPAIRED RETENTION BY ANGIOTENSIN-II MEDIATED BY THE AT(1) RECEPTOR [J].

LEE, EHY ;

MA, YL ;

WAYNER, MJ ;

ARMSTRONG, DL .

PEPTIDES, 1995, 16 (06) :1069-1071

[10] LOCALIZATION OF ANGIOTENSIN-IV BINDING-SITES TO MOTOR AND SENSORY NEURONS IN THE SHEEP SPINAL-CORD AND HINDBRAIN [J].

MOELLER, I ;

CHAI, SY ;

OLDFIELD, BJ ;

MCKINLEY, MJ ;

CASLEY, D ;

MENDELSOHN, FAO .

BRAIN RESEARCH, 1995, 701 (1-2) :301-306

← 1 2 →