Behavioral effects of angiotensin II microinjected into CA1 hippocampal area

被引：27

作者：

Belcheva, I ^{[1
]}

Georgiev, V ^{[1
]}

Chobanova, M ^{[1
]}

Hadjiivanova, C ^{[1
]}

机构：

[1] BULGARIAN ACAD SCI,INST PHYSIOL,LAB EXPT PSYCHOPHARMACOL,BU-1113 SOFIA,BULGARIA

来源：

NEUROPEPTIDES | 1997年 / 31卷 / 01期

关键词：

D O I：

10.1016/S0143-4179(97)90021-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The behavioral responses of rats to bilateral microinjections of angiotensin II (ATII) at doses of 0.1, 0.5 and 1.0 mu g into the hippocampal CA1 area of male Sprague-Dawley rats were studied. ATII affected locomotor activity (the number of horizontal and vertical movements) in a dose-related U-shaped manner. In the elevated plus-maze experiments, ATII at a dose of 0.1 mu g microinjected bilaterally into the CAI hippocampal area increased the number of entries into the open arms, suggesting some anxiolytic effect.

引用

页码：60 / 64

页数：5

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